Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

1977056

Reference Type

Journal Article

Subtype

Review

Title

Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models

Author(s)

Yaksh, TL

Year

1999

Is Peer Reviewed?

Journal

Trends in Pharmacological Sciences
ISSN: 0165-6147

Publisher

Elsevier

Volume

Issue

Page Numbers

329-337

Language

English

PMID

10431212

DOI

10.1016/S0165-6147(99)01370-X

Web of Science Id

WOS:000081911600005

URL

https://linkinghub.elsevier.com/retrieve/pii/S016561479901370X
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Abstract

Much research has been undertaken in the field of pain in an attempt to find an effective treatment. Insights into the underlying mechanisms of pain have been gained from studies using preclinical animal models (acute stimuli, post-tissue injury and peripheral nerve injury) and evaluating their similarity with the human condition. In this article, these pain models are summarized and the mechanisms of pain discussed in relation to spinal processing. In the context of this research the therapeutic potential of novel analgesics is highlighted as the future looks forward to the many possibilities that the targeted spinal delivery of drugs can bring.

Keywords

dependent protein-kinase; peripheral-nerve injury; tactile-evoked; allodynia; bovine chromaffin cells; necrosis-factor-alpha; neuropathic; dorsal horn; thermal hyperalgesia; formalin test; intrathecal; neostigmine

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