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Citation
Tags
HERO ID
1977056
Reference Type
Journal Article
Subtype
Review
Title
Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models
Author(s)
Yaksh, TL
Year
1999
Is Peer Reviewed?
1
Journal
Trends in Pharmacological Sciences
ISSN:
0165-6147
Publisher
Elsevier
Volume
20
Issue
8
Page Numbers
329-337
Language
English
PMID
10431212
DOI
10.1016/S0165-6147(99)01370-X
Web of Science Id
WOS:000081911600005
URL
https://linkinghub.elsevier.com/retrieve/pii/S016561479901370X
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Abstract
Much research has been undertaken in the field of pain in an attempt to find an effective treatment. Insights into the underlying mechanisms of pain have been gained from studies using preclinical animal models (acute stimuli, post-tissue injury and peripheral nerve injury) and evaluating their similarity with the human condition. In this article, these pain models are summarized and the mechanisms of pain discussed in relation to spinal processing. In the context of this research the therapeutic potential of novel analgesics is highlighted as the future looks forward to the many possibilities that the targeted spinal delivery of drugs can bring.
Keywords
dependent protein-kinase; peripheral-nerve injury; tactile-evoked; allodynia; bovine chromaffin cells; necrosis-factor-alpha; neuropathic; dorsal horn; thermal hyperalgesia; formalin test; intrathecal; neostigmine
Tags
IRIS
•
Formaldehyde [archived]
Reproductive and Developmental Effects
Screened
Title/abstract
Methodology/therapeutics
Retroactive RIS import
2015
FA DevRepro 072115
Methodology/Therapeutics-Population Criteria
•
IRIS Formaldehyde (Inhalation) [Final 2024]
Literature Indexing
Other sources and cited references
Literature Identification
Reproductive and Developmental Effects
Excluded
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