US EPA

1977074 

Journal Article 

Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer 

Ellerhorst, J; Troncoso, P; Xu, XC; Lee, J; Lotan, R 

1999 

1 

Urological Research
ISSN: 0300-5623
EISSN: 1434-0879 

27 

5 

362-367 

English 

10550525 

10.1007/s002400050164 

WOS:000083502600011 

http://://WOS:000083502600011
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Galectin-1 and galectin-3, two beta-galactoside-binding
proteins, have been suggested to play a role in the development and progression of cancer. We
have studied the expression of these molecules in normal human prostate tissue and prostate
adenocarcinoma. Immunohistochemistry was used to examine formalin-fixed, paraffin-embedded
sections of seven normal human prostates, eight cases of prostatic intraepithelial neoplasia
(PIN), 20 primary adenocarcinomas of the prostate, and 12 prostate cancer metastases. Galectin-1
was expressed in most cases of all four histologic types. In contrast, galectin-3 expression was
significantly decreased in primary carcinoma and metastatic disease compared with normal and
premalignant tissue. Galectin-3 expression in primary tumors tended to be less than that of
surrounding normal glands. We conclude that loss of galectin-3 expression may be associated with
the progression of prostate cancer. 

galectin-1; galectin-3; human prostate cancer; immunohistochemistry