US EPA

1977098 

Journal Article 

Clinical and pathologic features of oligodendrogliomas in two cats 

Dickinson, PJ; Keel, MK; Higgins, RJ; Koblik, PD; Lecouteur, RA; Naydan, DK; Bollen, AW; Vernau, W 

2000 

1 

Veterinary Pathology
ISSN: 0300-9858 

37 

2 

160-167 

English 

10714645 

10.1354/vp.37-2-160 

WOS:000085754600006 

http://://WOS:000085754600006
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Two oligodendrogliomas in two domestic cats involved mainly
the rostral brain stem, midbrain, fourth ventricle, and cerebellum. Both cats were aged neutered
males presenting with clinical neurologic deficits suggestive of a brain stem lesion. Magnetic
resonance imaging of both tumors demonstrated lesions with a pattern of heterogeneous contrast
enhancement and multifocal lesions in one cat. Routine cerebrospinal fluid analysis was normal in
one cat and suggestive of an inflammatory disease in the other. Oligodendroglioma cells were seen
in cytospin preparations of cerebrospinal fluid from both cats. In each cat, the tumors occurred
intraventricularly in the midbrain and fourth ventricle with aggressive intraparenchymal
infiltration. There was extensive growth into the basilar subarachnoid space of the midbrain and
brain stem in one cat. One tumor was well differentiated, and the other was an anaplastic
subtype. Immunostaining for several myelin- and oligodendroglia-specific antigens was negative
with formalin-fixed tumors and with unfixed frozen samples from one cat. In both tumors,
component cells of the intratumoral vascular proliferations were positive for human von
Willebrand factor VIII antigen or smooth muscle actin. Immunocytochemical reactivity for glial
fibrillary acidic protein identified both reactive astrocytes and a subpopulation of
minigemistocytes in both tumors. Ultrastructurally, the tumor cells were unremarkable except for
their prominent desmosomal junctions and paucity of microtubules. 

cats; cerebellum; cerebrospinal fluid; immunocytochemistry; magnetic resonance imaging; oligodendroglioma; ultrastructure