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HERO ID
1977462
Reference Type
Journal Article
Title
The relationship between cyclooxygenase-2 expression and characteristics of malignant transformation in human colorectal adenomas
Author(s)
Sheehan, KM; O'Connell, F; O'Grady, A; Conroy, RM; Leader, MB; Byrne, MF; Murray, FE; Kay, EW
Year
2004
Is Peer Reviewed?
Yes
Journal
European Journal of Gastroenterology and Hepatology
ISSN:
0954-691X
EISSN:
1473-5687
Volume
16
Issue
6
Page Numbers
619-625
Language
English
PMID
15167166
DOI
10.1097/01.meg.000108313.52416.38
Web of Science Id
WOS:000221874300017
URL
http://
://WOS:000221874300017
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Abstract
BACKGROUND AND AIMS:
Cyclooxygenase 2 (COX-2) is a target of aspirin and other non-steroidal anti-inflammatory drugs and is implicated in the pathogenesis of colorectal cancer. The objective of this study was to evaluate the extent of COX-2 in pre-malignant colorectal polyps and to assess the relationship between COX-2 and the level of dysplasia in these lesions.
METHODS:
Whole polypectomy specimens were retrieved from 123 patients by endoscopic or surgical resection. Following formalin fixation and paraffin embedding, the polyps were evaluated histologically for size, type and grade of dysplasia. The extent of COX-2 expression was measured by the avidin-biotin immunohistochemical technique using a monoclonal COX-2 antibody. The extent of COX-2 expression was graded according to percentage epithelial COX-2 expression.
RESULTS:
The polyps were of the following histological types: 10 hyperplastic, 35 tubular adenomas, 61 tubulovillous adenomas and 17 villous adenomas. Twenty showed mild dysplasia, 65 moderate dysplasia, and 28 focal or severe dysplasia (including eight with focal invasion). The average polyp size was 1.7 cm. Nine hyperplastic polyps were COX-2-negative and one was COX-2-positive. COX-2 expression was more extensive in larger polyps and in polyps with a higher villous component. There was a significant increase in the extent of COX-2 protein with increasing severity of dysplasia. Within a polyp, there was a focal corresponding increase in COX-2 expression within epithelium showing a higher grade of dysplasia.
CONCLUSIONS:
COX-2 expression is related directly to colorectal adenomatous polyp size, type and grade of dysplasia. This suggests that the role of COX-2 in colorectal cancer may be at an early stage in the adenoma-to-carcinoma sequence and supports the suggestion that inhibition of COX-2 may be useful chemoprevention for this disease.
Keywords
cyclooxygenase 2; colon carcinogenesis; colorectal adenoma; colorectal cancer
Tags
IRIS
•
Formaldehyde
Reproductive and Developmental Effects
Screened
Title/abstract
Methodology/therapeutics
Human Respiratory Pathology
Found
Retroactive RIS import
2013
Respiratory Pathology Pubmed WOS Toxline
Not About Formaldehyde
2014
Respiratory Pathology Pubmed_WOS_Toxline_090414
Not About Formaldehyde
2015
FA DevRepro 072115
Methodology/Therapeutics-Population Criteria
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