US EPA

1986905 

Journal Article 

Review 

Bovine respiratory syncytial virus 

Brodersen, BW 

2010 

1 

Veterinary Clinics of North America: Food Animal Practice
ISSN: 0749-0720 

26 

2 

323-333 

English 

20619187 

10.1016/j.cvfa.2010.04.010 

WOS:000280482000010 

http://://WOS:000280482000010
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Bovine respiratory syncytial virus (BRSV) is a major cause of respiratory disease and a major contributor to the bovine respiratory disease (BRD) complex. BRSV infects the upper and lower respiratory tract and is shed in nasal secretions. The close relatedness of BRSV to human respiratory syncytial virus (HRSV) has allowed researchers to use BRSV and HRSV to elucidate the mechanisms by which these viruses induce disease. Attempted vaccine production using formalin-inactivated vaccine resulted in exacerbated disease when infants became exposed to HRSV. Cattle vaccinated with formalin-inactivated virus had enhanced disease when inoculated with BRSV. This article discusses various aspects of BRSV, its epidemiology, pathogenesis, diagnostic tests, immunity, and vaccination. 

Bovine respiratory syncytial virus; BRSV; BRSV diagnosis; Bovine respiratory disease complex; BRD