US EPA

199841 

Journal Article 

Effects of nanometer sized silver materials on biological toxicity during zebrafish embryogenesis 

Yeo, MK; Kang, M 

2008 

Yes 

Bulletin of the Korean Chemical Society
ISSN: 0253-2964
EISSN: 1229-5949 

29 

6 

1179-1184 

WOS:000258606000018 

http://journal.kcsnet.or.kr/main/j_search/j_abstract_view.htm?code=B080618&qpage=j_search&spage=b_bkcs&dpage=ar
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Commercial nanometer sized silver is widely used for its antibacterial effect; however, nanoparticles may also have ecotoxicological effects after being discharged into water. Nanometer sized silver can flow into aquatic environments, where it can exert a variety of physiologically effects in living organisms, including fish. The present study aimed to investigate the effect of nanometer sized silver on the development of zebrafish embryos, analyze the properties of commercial nanometer sized silver and define the toxicity relationship between embryogenesis and hatched flies. The commercial nanometer sized silver was analyzed in the Ag+ ion form. The hatch rate decreased in the nano-silver exposed groups (10 and 20 ppt); furthermore, the hatched flies had an abnormal notochord, weak heart beat, damaged eyes and curved tail. The expression of the Sel N1 gene decreased in the nano-silver exposed groups, and the catalase activities of the exposed groups increased relative to those in the control group. Therefore, the Ag+ ions in commercial nanometer sized silver could accumulate in aquatic environments and seriously damage the development of zebrafish embryos. 

Nanometer sized silver; Biological toxicity; Zebrafish embryos