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2007688 
Journal Article 
Oxidative stress-mediated signaling pathways: A review 
Yin, Jie; Ren, W; Wu, X; Yang, G; Wang, J; Li, T; Ding, J; Cai, L; Su, D 
2013 
Yes 
Journal of Food, Agriculture and Environment
ISSN: 1459-0255 
11 
2 
132-139 
WOS:000321912100001 
Once the cells are challenged by intra-and extracellular environmental stimuli such as nitric oxide, calcium and pathogenic organisms, the oxidative balance between reactive oxygen species (ROS) (such as O-2(center dot-), H2O2, OH center dot) production and antioxidant defense systems (such as glutathione reductase and catalase) is broken, resulting in accumulation of ROS within cells. ROS is linked with various cellular signaling pathways, including the nuclear factor erythroid 2-related factor 2/Keap1(Nrf2/Keap1), mitogen-activated protein kinases (MAPKs), the nuclear factor kappa B (NF-kappa B), protein kinase C (PKC), signal transducers and activators of transcription 3 (STAT3), and peroxisome proliferator-activated receptor-gamma (PPAR gamma), which engaged in regulating pro-oxidant genes and antioxidant genes expression, and mediate cells oxidative injury and antioxidant defense system. This article therefore mainly focuses on: 1) the production of ROS; 2) Nrf2/Keap1, MAPKs, NF-kappa B, PKC, STAT3, and PPAR gamma activation mechanism by ROS. 
Molecular mechanism; signalling; oxidative stress