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2033151 
Journal Article 
N-H Activation of Amines and Ammonia by Ru via Metal-Ligand Cooperation 
Khaskin, E; Iron, MA; Shimon, LJW; Zhang, J; Milstein, D 
2010 
Yes 
Journal of the American Chemical Society
ISSN: 0002-7863
EISSN: 1520-5126 
132 
25 
8542-+ 
English 
20524608 
WOS:000279196500008 
A nonoxidative addition pathway for the activation of NH bonds of ammonia and amines by a Ru(II) complex is reported. The pincer complex 1 cleaves N-H bonds via metal-ligand cooperation involving aromatization of the pincer ligand without a change in the formal oxidation state of the metal. Electron-rich N-H bond substrates lead to reversible activation, while electron-poor substrates result in stable activation products. Isotopic labeling studies using ND(3) as well as density functional theory calculations were used to shed light on the N-H activation mechanism.