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2048933 
Journal Article 
The applicability of the ADI (Acceptable Daily Intake) for food additives to infants and children 
Ostergaard, G; Knudsen, I 
1998 
Yes 
Food Additives and Contaminants
ISSN: 0265-203X
EISSN: 1464-5122 
BIOSIS/98/10759 
15 
SUPPL 
63-74 
English 
9602914 
BIOSIS COPYRIGHT: BIOL ABS. Children are not little adults. Children may respond differently from adults because they are in a state of growth and development; or because of differences in toxicokinetics or toxicodynamics. Infants and children are often assumed to be more susceptible to toxic effects, but this generalization is founded on assumptions rather than on facts. Available data are mostly concerned with toxicity and therapeutic effects of pharmaceuticals, while the effects in children of industrial chemicals are less well documented. Childhood is characterized by growth and development. Toxicants may interfere with these processes, and therefore toxic exposure may have more serious consequences for children than for adults, irrespective of sensitivity. Immature physiological functions of the foetus and young child theoretically make these age groups more vulnerable to toxicants, at least up to 1 year of age. The existing data on effects of chemical exposure in children point in the direct 
Biochemistry; Biophysics; Nutrition; Nutritional status; Food technology; Poisoning; Animals, laboratory; Child development; Pediatrics; Embryology; Fetal development; Animals; Hominidae