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2054138 
Journal Article 
Aquagenic palmoplantar keratoderma 
Yan, AC; Aasi, SZ; Alms, WJ; James, WD; Heymann, WR; Paller, AS; Honig, PJ 
2001 
Yes 
Journal of the American Academy of Dermatology
ISSN: 0190-9622
EISSN: 1097-6787 
Elsevier 
44 
4 
696-699 
English 
11260552 
WOS:000167768000027 
Aquagenic palmoplantar keratoderma is an acquired condition characterized by burning and edema limited to the hands after brief immersion in water. The 3 patients described possess a striking similarity to those with transient reactive papulotranslucent acrokeratoderma. All 3 patients manifested the "hand-in-the-bucket" sign, having presented to a physician with a hand immersed in a bucket of water to more promptly demonstrate the physical findings. Aluminum chloride hexahydrate represents a potentially valuable therapeutic option for this unusual condition.