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2054926 
Journal Article 
Polycystic ovary syndrome treated with laparoscopic ovarian drilling with a harmonic scalpel - A prospective, randomized study 
Takeuchi, S; Futamura, N; Takubo, S; Noda, N; Minoura, H; Toyoda, N 
2002 
Yes 
Journal of Reproductive Medicine
ISSN: 0024-7758
EISSN: 1943-3565 
47 
10 
816-820 
English 
12418063 
WOS:000178826800003 
OBJECTIVE: To evaluate the endocrinologic profile and reproductive outcome after laparoscopic drilling using a harmonic scalpel for polycystic ovarian syndrome (PCOS) in clomiphene-resistant infertile women.

STUDY DESIGN: We performed a prospective, randomized study of 34 infertile women with PCOS. Group A (17 women) underwent laparoscopic ovarian drilling using a harmonic scalpel laser. Group B (control group, 17 women) underwent laparoscopic ovarian drilling using a neodymium-yttrium-aluminum-garnet laser. Change in the hormonal profile after surgery, ovulation rate and pregnancy rate were compared between groups A and B.

RESULTS: LH and testosterone serum levels and the LH-FSH ratio showed a statistically significant reduction after surgery, and the spontaneous ovulation rate was 94% in both groups. The cumulative pregnancy rates within two years of follow-up were 77% in group A and 60% in group B.

CONCLUSION: Laparoscopic ovarian drilling using a harmonic scalpel is an effective treatment for PCOS in clomiphene-resistant, anovulatory women: it results in ovulation and conception without major complications. 
polycystic ovary syndrome; laparoscopic surgical procedures; harmonic scalpel; ovarian drilling