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2057278 
Journal Article 
MECHANISM OF ANTIPERSPIRANT ACTION OF ALUMINUM SALTS 
Holzle, E; Kligman, AM 
1979 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
IPA/80/376040 
30 
5 
279-295 
eng 
WOS:A1979HR60900003 
IPA COPYRIGHT: ASHP The mechanism of action of aluminum chloride (I) was studied in 60 healthy young adults of both sexes. The test areas were either the bolar forearm or the lower back. I, 200 mul of the 20% aqueous solution, was applied to the subjects for periods ranging from 15 min to 24 hr. Immediately after exposure, an amorphous aluminum containing cast was demonstrated in the sweat ducts by the fluorescent morin stain. Histologically, the luminal cells of the acrosyringium were damaged and soon sloughed, fusing with the cast. There were no inflammatory changes. The physically occluded ducts did not sweat for 2 to 3 weeks until the normal process of cell renewal resulted in replacement of the acrosyringium. It was concluded that anhidrosis induced by aluminum salts has unique characteristics which distinguish it from all other procedures which interfere with sweat delivery.