US EPA

2057283 

Journal Article 

FACTORS INFLUENCING THE ANTI-PERSPIRANT ACTION OF ALUMINUM SALTS 

Holzle, E; Kligman, AM 

1979 

0 

Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 

IPA/80/376033 

30 

6 

357-367 

eng 

WOS:A1979HW80500004 

IPA COPYRIGHT: ASHP Methods for enhancing the antiperspirant activity of aluminum salts were studied in 97 young adults. Salts used included aluminum chloride hexahydrate (aluminum chloride), aluminum hydroxychloride (aluminum chlorohydrate) and aluminum sulfate (aluminum sulfate anhydrous). Occlusion greatly promoted anhidrosis in comparison to frequent open applications, iontophoretic application of various concentrations of aluminum salts paradoxically failed to inhibit sweating, delipidizing the skin with fat solvents had no effect, surfactants at nonirritating concentrations did not enhance the antiperspirant effect, massaging for 10 min during repeated applications greatly intensified the antiperspirant effect, and the antiperspirant effect of aluminum chloride was completely abolished when the subject was sweating during the exposure. Brief sweating prior to exposure greatly increased sweat suppression.