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2057579 
Journal Article 
EVALUATION OF ANTACID SUSPENSIONS CONTAINING ALUMINUM HYDROXIDE AND MAGNESIUM-HYDROXIDE 
Hem, SL; White, JL; Buehler, JD; Luber, , JR; Grim, WM; Lipka, EA 
1982 
Yes 
American Journal of Hospital Pharmacy
ISSN: 0002-9289 
IPA/83/512026 
39 
11 
1925-1930 
eng 
7148862 
WOS:A1982PP33300029 
IPA COPYRIGHT: ASHP Liquid antacid suspensions containing aluminum hydroxide and magnesium hydroxide were evaluated for composition, antacid properties, and product quality. Several samples from 36 products were examined. The equivalent aluminum oxide and magnesium hydroxide content was determined by chelatometric titration, and the sodium content was determined by flame photometry. The antacid properties measured were acid consuming capacity, antacid effectiveness, and pH-stat titration. Content uniformity, consistency of the antacid properties, and microbiological content were examined. Results showed that the ratio of the percentage of equivalent aluminum oxide to the percentage of magnesium hydroxide ranged from 1:0.6 to 1:3.5. Based on a daily dose of 280 meq of antacid, the sodium content varied from less than 2% to approximately 45% of the 500 mg/day of sodium allowed in a sodium restricted diet. Some of the antacids neutralized |GT/ 90% of the theoretical quantity of acid during the estimated gastric residence time of 15 min. Approximately 4% of the samples contained unacceptable numbers of bacteria. It is concluded that an antacid suspension cannot be adequately evaluated by a single test. Evaluation should be based on several characteristics including sodium content, time and volume required to neutralize a given amount of acid, and uniformity of content.