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2059485 
Journal Article 
ALUMINUM PERTURBS OSCILLATORY PHOSPHOINOSITIDE-MEDIATED CALCIUM SIGNALING IN HORMONE-STIMULATED HEPATOCYTES 
Schofl, C; Sanchezbueno, A; Dixon, CJ; Woods, NM; Lee, JAC; Cuthbertson, KSR; Cobbold, PH; Birchall, JD 
1990 
Yes 
Biochemical Journal
ISSN: 0264-6021
EISSN: 1470-8728 
269 
2 
547-550 
English 
2167073 
WOS:A1990DQ81100042 
Aluminium is known to be toxic to cells from bone, brain and bone marrow but the molecular target(s) affected by Al3+ are not known. We show here that Al3+ disrupts the oscillatory free Ca2+ responses of hepatocytes exposed to the Ca2(+)-mobilizing agonist phenylephrine. Al3+ initially increases the frequency of the oscillations and later induces broad Ca2+ spikes lasting several minutes. These broad spikes persist after removal of both agonist and Al3+ from the medium. In the absence of agonist, Al3+ has no effect on free Ca2+. The data suggest that some component(s) of the receptor-phosphoinositide-Ca2+ signalling pathway might be the site at which Al3+ exerts toxic effects.