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2064896 
Journal Article 
Statistical evaluation of vehicle effect on antiperspirant activity with a limited number of subjects 
Osborne, GE; Lausier, JM; Lawing, WD; Smith, M 
1982 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
IPA/83/505113 
Soc 
REF 20 
179-191 
eng 
IPA COPYRIGHT: ASHP The efficacy of aluminum chlorhydrate (aluminum chlorohydrate; I), solubilized into a cream base, an aqueous lotion, and a hydroalcoholic base, and suspended in a solid stick, was evaluated in 8 subjects (6 females and 2 males) during normal work days in each subject's normal work environment. Aluminum chlorhydroxy allantoinate (alcloxa) was incorporated into all the vehicles for its therapeutic and cosmetic properties. The 4 vehicles containing I were compared for efficacy by a gravimetric procedure. Results showed that the carrier vehicle does not affect antiperspirant efficacy. However, a release rate of the active ingredient from the vehicle plays an important role in antiperspirant efficacy, as observed with I in solution in the cream base, aqueous lotion, and hydroalcoholic base vs that in suspension in the solid stick. The antiperspirant treatment response, in terms of percent sweat reduction (in decreasing order of effectiveness) was: lotion, 38.0%; hydroalcoholic solution, 32.4%; cream, 31.8%; and stick, -6.2%.