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2065433 
Journal Article 
New nonsteroid nonantibiotic skin medicaments 
Copeman, PWM; Selwyn, S 
1975 
Yes 
British Medical Journal (International Edition)
ISSN: 0959-8146
EISSN: 0959-535X 
IPA/76/204112 
Med 
REF 5 
eng 
IPA COPYRIGHT: ASHP Miol lotion and cream preparations (containing aluminum chlorhydroxyallantoinate, calcium chloride, camphor, chlorphenesin, magnesium chloride and sodium chloride) were used on 120 patients whose diagnoses were stasis ulcers (44), varicose eczema (36), varicose eczema with superimposed contact eczema (20), severe intertrigo (13), cutaneous angiitis (4), and single cases of Darier's disease, widespread capillary hemangioma with ulceration, and benign familial chronic pemphigus. In all cases prolonged conventional treatment with corticosteroids--often with antibiotics--was unsuccessful. In every case the lesions were colonized by pathogenic bacteria or yeasts. Staphylococcus aureus predominated in 69 patients, Gram negative bacilli (mainly Pseudomonas aeruginosa and Proteus species) in 40--chiefly in leg ulcers--Candida albicans in 7 and Streptococcus pyogenes in 4 patients. The preparations were well tolerated by all except 4 patients who complained of local pain in the margins of ulcers. Most patients gained early relief from pre-existing pruritus. In 96 patients substantial clinical improvement was maintained for at least one month. Many of the indolent ulcers healed with surprising speed as did varicose exzemas. Gram negative bacilli were suppressed in all except 3 cases of leg ulcer where persistent P. aeruginosa paralleled an inadequate clinical response. C. albicans and S. pyogenes were eliminated during treatment and so was S. aureus generally, but, as was found using topical antibiotics, this organism persisted at lower population levels in 27 patients--including 13 who made satisfactory clinical progress.