US EPA

2065796 

Journal Article 

Magnesium induced bradycardia 

Berns, AS; Kollmeyer, KR 

1976 

Yes 

Annals of Internal Medicine
ISSN: 0003-4819
EISSN: 1539-3704 

IPA/77/255014 

Intern 

REF 4 

760-761 

eng 

IPA COPYRIGHT: ASHP A case report of mild hypermagnesemia (serum magnesium concentration, 3.3 to 4.8 meq/l), responsible for severe junctional bradycardia is reported in a 62-yr-old woman with chronic renal insufficiency, who had been receiving Maalox (aluminum hydroxide, combination, magnesium hydroxide) for a prepyloric gastric ulcer. On the seventh hospital day an ECG showed junctional bradycardia with a heart rate of 40 per min. Serum magnesium was 4.5 meq/l. Aluminum hydroxide therapy for the ucler was substituted for Maalox. Serum, magnesium dropped to 3 meq/l with a reversion to normal sinus rhythm. Maalox was reinstated 4 days after the first episode of abnormal rhythm. Five days later junctional bradycardia redeveloped with a serum magnesium level of 4.8 meq/l. Again antacid withdrawal accompanied a fall in serum magnesium and reversion to normal sinus rhythm. The patient had not received any digitalis preparations throughout the treatment regimen. Hypermagnesemia should be considered when evaluating any patient with bradycardia especially when renal insufficiency is present.