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2065933 
Journal Article 
Studies on the drug interaction of diltiazem. Part 1. Effects of co-administered drugs and dosing conditions on the bioavailability of diltiazem 
Etoh, A; Kohno, J 
1983 
1 
Yakugaku Zasshi
ISSN: 0031-6903
EISSN: 1347-5231 
IPA/85/591089 
Pharm 
Yakugaku Zasshi 
426-433 
IPA COPYRIGHT: ASHP The effects of dipyridamole (I), propranolol, magnesium aluminum silicate, ethyl alcohol (II), food and sleep on the bioavailability of diltiazem (III) were studied in dogs and humans in single oral doses. In dogs, the absorption of III was delayed on the co-administration of food and antacid. Other bioavailability parameters such as plasma levels achieved and maximal blood concentration and area under the curve (AUC) were unchanged. Administration of II and I markedly increased the peak level and AUC of III. Biological half-lives were not altered as compared with III alone on any occasion. In healthy subjects, sleep caused a delay in III absorption. The results in dogs and humans were not parallel except time to reach the peak level. The relationship between the number of co-administered drugs and the steady-state plasma III levels was not significant.