Evaluation of disintegration of hard gelatin capsules with a static beaker method based on photography | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2065972

Reference Type

Journal Article

Title

Evaluation of disintegration of hard gelatin capsules with a static beaker method based on photography

Author(s)

Hannula, AM; Marvola, M; Rajamaki, M

Year

1991

Is Peer Reviewed?

Yes

Journal

Acta Pharmaceutica
ISSN: 1330-0075

Report Number

IPA/92/1003188

Volume

Fenn

Issue

REF 16

Page Numbers

229-236

Abstract

IPA COPYRIGHT: ASHP Disintegration of ibuprofen capsules containing 4 different additives, sodium bicarbonate, calcium carbonate, tartaric acid, or aluminum hydroxide (aluminium hydroxide), with previously known dissolution and absorption properties was tested both according to the European Pharmacopeia and using the static beaker method extended by means of photography and the use of 2 different pH values. The static beaker method with floating capsules made it easy to record the precise moment of disintegration, while photography (both black and white and color) gave detailed information about the process. With this method a clear rank order correlation existed between previous dissolution and absorption data, while the official test, by being too drastic, hid the effects of formulation variables.