Health & Environmental Research Online (HERO)


Print Feedback Export to File
2066150 
Journal Article 
Endoscopic evaluation of the effects of aspirin, buffered aspirin, and enteric-coated aspirin on gastric and duodenal mucosa 
Lanza, FL; Royer, GL; Nelson, RS 
1980 
1 
New England Journal of Medicine
ISSN: 0028-4793
EISSN: 1533-4406 
IPA/80/404025 
Engl 
REF 20 
136-138 
eng 
IPA COPYRIGHT: ASHP The effects of aspirin (I) administered alone as regular and enteric coated (Ecotrin) tablets or in combination with magnesium aluminum hydroxide (Ascriptin A) on the gastric and duodenal mucosa were examined endoscopically in 20 healthy volunteers (aged 21-45 yr). The subjects were randomized into 4 parallel treatment groups, each containing 5 subjects. Group 4 received placebo tablets. Each group received test medication for 7 consecutive days, which, in the case of all I compounds, was administered as three 325 mg tablets 4 times a day (3,900 mg/day). Results showed that at the doses employed, regular and buffered I consistently produced significantly greater mucosal damage than did enteric coated I or placebo in the stomach and duodenum. The difference in the mucosal damage caused by regular and buffered I was insignificant.