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2066184 
Technical Report 
Comparative bioavailability of aspirin from buffered, enteric coated and plain preparations 
Latini, R; Cerletti, C; Degaetano, G; Dejana, E; Galletti, F; Et al 
1986 
IPA/87/735069 
J 
REF 23 
313-318 
English 
IPA COPYRIGHT: ASHP A randomized, crossover study was undertaken in 6 healthy male volunteers to determine the bioavailability of 2 buffered formulations of aspirin (I), Ascriptin and Ascriptin A (aluminum hydroxide, combination, aspirin, magnesium hydroxide), a compressed I tablet (Aspro), and an enteric coated I tablet (Cemirit). Results showed peak plasma I levels between 10 and 50 min after the 2 buffered and plain tablets. The peak after the enteric coated preparation was statistically later, between 60 and 120 min. Ascriptin A/D gave mean peak levels of approximately 6.5 mcg/ml that were significantly higher than the compressed and enteric coated tablets. Plasma concentrations of I were not detectable in 3 subjects after the compressed tablet and in 2 subjects after the enteric coated preparation. There was no significant difference in the elimination half-life between the various preparations. The half-life values ranged between 14 and 58 min.