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2066329 
Journal Article 
Effects of antacid and propantheline on the absorption of oral ranitidine 
Donn, KH; Eshelman, FN; Plachetka, JR; Fabre, L; Powell, JR 
1984 
1 
Pharmacotherapy
ISSN: 0277-0008
EISSN: 1875-9114 
IPA/85/618052 
VOL 4 ISS Mar 
REF 24 
eng 
IPA COPYRIGHT: ASHP The effects of propantheline bromide (Pro-Banthine; I) and a combination of aluminum hydroxide and magnesium hydroxide (Maalox) on ranitidine hydrochloride (Zantac; II) absorption were studied in 12 subjects. Ranitidine 150 mg was administered alone, with 30 ml of antacid or preceded by 15 mg I. Ten serum samples were obtained over 12 h during each treatment period for measurement of II blood levels. The antacid had no significant effect on II absorption, but I increased the relative bioavailability of II by 22%. In addition, there was a trend for I to increase the maximum II serum levels and the time to maximum serum levels.