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2066505 
Technical Report 
Hyperuricemia, renal failure, and elevated creatine phosphokinase after amoxapine overdose 
Thompson, M; Dempsey, W 
1983 
IPA/84/563022 
Pharm 
REF 10 
579-581 
eng 
IPA COPYRIGHT: ASHP A case is reported of hyperuricemia, acute renal failure, and elevated creatine phosphokinase in a 24-yr-old male who ingested amoxapine (I) 4 g (40 tablets of 100 mg) 12-18 h prior to hospital admission. Treatment for a generalized seizure consisted of phenytoin sodium 500 mg IV; magnesium sulfate 30 g administered by nasogastric tube; and naloxone hydrochloride 0.4 mg IV. Subsequent therapy followed with allopurinol, sodium bicarbonate, acetazolamide, aluminum hydroxide, and furosemide. The patient was awake and able to respond to questioning on the seventh day. Brief awakenings had occurred after 2 doses of physostigmine salicylate during this time. Normal renal status and laboratory values were evident in a one month follow-up. It was concluded that further research is needed to determine the pathogenesis leading to acute renal failure and high creatine phosphokinase values after amoxapine overdose.