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2068038 
Technical Report 
Preparation of 3,5-diaminobenzyl alcohol and its iodinated derivatives 
Hebky, J; Polacek, J 
1970 
IPA/70/06396 
Czech 
REF 8 
667-674 
eng 
IPA COPYRIGHT: ASHP The preparation of starting compounds for the synthesis of potential radiopaque diagnostic agents, which should possess a high iodine content and a high resorption power in the gastrointestinal tract, is reported. 3,5-Diaminobenzyl alcohol was prepared by reduction of ethyl or methyl 3,5-diaminobenzoate with lithium aluminum hydride (yield, 70%) or sodium bis(2-methoxyethoxy)aluminum hydride (yield, 82%). The 3,5-diaminobenzyl alcohol is considerably soluble in water and shows the typical behavior of phenylenediamines, namely, oxidation and coloration when exposed to light and air. Its stability is much greater in the form of salts with acids, e.g., as the dihydrochloride.