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2068073 
Journal Article 
Inhibition of palmar skin conductance in mice by antiperspirants' relative anhidrotic activities 
Marcy, R; Quermonne, MA 
1976 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
IPA/77/235154 
Soc 
REF 43 
333-344 
eng 
IPA COPYRIGHT: ASHP In order to systematically test the anhidrotic activities of potential antiperspirants in relation to a standard or to cross compare various formulations, an experimental method that uses mice was developed. The antiperspirant was applied to footpads with a rotating applicator which was gripped by mice; thus preventing the animals from removing it by grooming. The anhidrotic effect was evaluated by lowering palmar skin conductance. This was read with a conductance meter built so that the mice themselves could grasp the electrodes by reflex action. Several topical anhidrotics were tested to determine the intensity, duration, and after washing persistence of their anhidrotic activity. The calculation of the concentrations, which inhibit sweating by 50% (weight/volume and molar anhidrotic concentrations 50) and of the relative activities, allows the objective comparison of the anhidrotics. Reliability and utility of the test are discussed. The following chemicals, dissolved in distilled water, were used: tannic acid, trichloracetic acid, zinc chloride, zinc phenolsulfonate, aluminum sulfate, aluminum hydroxychloride, formaldehyde, glutaraldehyde, and isopropamide iodide.