Formulation and stability of an oral mouthwash to treat symptoms of mucositis | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2073155

Reference Type

Technical Report

Title

Formulation and stability of an oral mouthwash to treat symptoms of mucositis

Author(s)

Sandmann, BJ; Sokol, SA; Buck, GW

Year

1996

Report Number

IPA/96/1097122

Volume

VOL 53 ISS Jun 1996

Issue

Language

eng

Abstract

IPA COPYRIGHT: ASHP Formulations for a mouthwash, used for mucositis in cancer patients, containing lidocaine, diphenhydramine, and sucralfate were studied for stability. Gelling was observed for combinations of 2% lidocaine viscous and sucralfate suspension. When buffered above pH 5 with phosphate buffer injection, the mouthwash did not gel and retained a viscosity beneficial to coating epithelial tissue in the mouth. The stabilities of lidocaine and diphenhydramine were studied for six weeks by HPLC. Aluminum from the sucralfate was determined by inductively coupled plasma over the same time period. The formulation was determined to be greater than 90% stable for six weeks. Mechanism of gel formation was studied by FTIR. A pilot study to determine acceptability of the mouthwash to cancer patients is in progress.