US EPA

2078067 

Journal Article 

Pulmonary and hepatic granulomatous disorders due to the inhalation of cement and mice dusts 

Pimenthel, JC; Menezes, AP 

1978 

1 

Thorax
ISSN: 0040-6376
EISSN: 1468-3296 

HEEP/79/00247 

33 

2 

219-227 

HEEP COPYRIGHT: BIOL ABS. Hepatic and pulmonary granulomas were observed in 2 workers exposed, respectively, to Portland cement and to muscovite dusts. The pulmonary lesions in the patient exposed to cement consisted of histiocytic granulomas and irregular fibrohyaline scars. In the patient exposed to mica, a diffuse thickening of all interalveolar septa due to new formation of reticulin and collagen fibers and proliferation of fibroblasts and histiocytes were seen. In the liver the following pathological findings were observed: focal or diffuse swelling of sinusoidal lining cells, sarcoid-type granulomas, and, in the case of mica exposure, perisinusoidal and portal tract fibrosis. Abundant inclusions of the inhaled material were identified within the pulmonary and hepatic lesions by histochemical and X-ray diffraction techniques.