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2123896 
Journal Article 
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model 
Umemura, T; Kodama, Y; Nishikawa, A; Hioki, K; Nomura, T; Kanki, K; Kuroiwa, Y; Ishii, Y; Kurokawa, Y; Hirose, M 
2006 
Yes 
Cancer Letters
ISSN: 0304-3835
EISSN: 1872-7980 
231 
2 
314-318 
English 
16399233 
WOS:000234955900020 
A 9-week in vivo rasH2/butylhydroxytoluene (BHT) model for the detection of genotoxic lung carcinogens was validated, using six potent positive test compounds, dimethylnitrosamine (DMN; 15 mg/kg, i.p.), diethylnitrosamine (DEN; 100 mg/kg, i.p.), ethylnitrosourea (ENU 120 mg/k,g, i.p.), 3-methylcholanthrene (MC; 100 mg/kg, i.p.), 7,12-dimethylbenz(a)anthracene (DMBA; 5 mg/kg, i.g.) and benzo(a)pyrene (B(a)P; 80 mg/kg, i.p.), each given to rasH2 mice of both genders by single administration for initiation followed by promoter BHT treatment. Statistically significant increase in the incidence and multiplicity of lung tumors was observed in rasH2 mice treated with BHT following exposure to all of the carcinogens tested. The data overall suggest the rasH2/BHT model to be it powerful screening tool for genotoxic lung carcinogens. (c) 2005 Elsevier Ireland Ltd. All rights reserved. 
rasH2 mice; in vivo assay; BHT; genotoxic lung carcinogen