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2123905 
Journal Article 
Substituted phenanthrenes with basic amino side chains: A new series of anti-breast cancer agents 
Shagufta; Srivastava, AK; Sharma, R; Mishra, R; Balapure, AK; Murthy, PSR; Panda, G 
2006 
Yes 
Bioorganic & Medicinal Chemistry
ISSN: 0968-0896
EISSN: 1464-3391 
14 
5 
1497-1505 
English 
16249093 
WOS:000235244400021 
In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC50 in the range of 3.53-22.25 mu M. One of the compounds 15ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen. (c) 2005 Elsevier Ltd. All rights reserved. 
substituted phenanthrenes; anti-breast cancer agents; basic amino side chain