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2126161 
Journal Article 
HEPATIC-METABOLISM OF 7,12-DIMETHYLBENZ(A)ANTHRACENE IN MALE, FEMALE, AND OVARIECTOMIZED SPRAGUE-DAWLEY RATS 
Vater, ST; Baldwin, DM; Warshawsky, D 
1991 
Yes 
Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445 
BIOSIS/91/09170 
51 
2 
492-498 
English 
1898712 
WOS:A1991ET78900006 
BIOSIS COPYRIGHT: BIOL ABS. Dimethylbenz(a)anthracene (DMBA) is a potent inducer of mammary tumors in intact female Sprague-Dawley rats, but not in males or ovariectomized females (OVX). Qualitative and quantitative aspects of hepatic metabolism of DMBA were examined in these three groups of rats, using the nonrecirclating perfused liver, to determine whether the production of proximate carcinogenic metabolites of DMBA by the liver differed among these groups in the same manner as does sensitivity to tumour induction. DMBA was infused into the liver at a constant rate for 60 min. Rates of appearance of DMBA and its metabolites were measured in perfusate and bile during the infusion period and the first 60 min thereafter. The maximum rate of appearance of total metabolites in the perfusate, seen at the end of the infusion period, was highest in the intact female (2.6 | 0.3 nmol/(g/(g/(g showed the same order as those seen in the perfusate. The major metabolite extracted from the perfusate in all thr