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2127555 
Journal Article 
Tea polyphenols as inhibitors of mutagenicity of major classes of carcinogens 
Weisburger, JH; Hara, Y; Dolan, L; Luo, FQ; Pittman, B; Zang, E 
1996 
1 
Mutation Research: Genetic Toxicology
ISSN: 0165-1218 
Elsevier B.V. 
EMIC/101740 
371 
1-2 
57-63 
English 
8950350 
WOS:A1996VU93200006 
Previous research suggested that the mutagenicity of some genotoxic carcinogens, mainly heterocyclic amines, was decreased by green or black tea extracts, or tea polyphenol fractions. Thus, it seemed important to test a variety of genotoxic carcinogens with distinct chemical structures and means of biochemical activation as regards modification of mutagenicity in appropriate strains of Salmonella typhimurium by 3 concentrations of polyphenols 60, 100, or B, standard commercial polyphenol preparations from green or black tea. Polyphenols sharply decreased the mutagenicity of a number of aryl- and heterocyclic amines, of aflatoxin B-1, benzo[a]pyrene, 1,2-dibromoethane, and more selectively, of 2-nitropropane, all involving an induced rat liver Sg fraction. Good inhibition was found with 2 nitrosamines that required a hamster S9 fraction for biochemical activation. No effect was found with 1-nitropyrene, and with the direct-acting (no S9) 2-chloro-4-methylthiobutanoic acid. Thus, with some exceptions, polyphenols considerably decreased the mutagenicity of diverse types of carcinogens. 
green tea; black tea; polyphenol; polyphenon; mutagenicity; ames test; genotoxic carcinogens; inhibition; rat S9 fraction; hamster S9 fraction