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2128508 
Journal Article 
Review 
Trichloroethylene and Parkinson Disease 
Zaheer, F; Slevin, JT 
2011 
1 
Neurologic Clinics
ISSN: 0733-8619
EISSN: 1557-9875 
W.B. Saunders Co. 
Netherlands 
29 
3 
657-+ 
English 
21803216 
WOS:000294373800009 
Multiple genetic and environmental etiologies have been implicated in the pathogenesis of idiopathic Parkinson disease. Recent observations have suggested an association between chronic exposure to trichloroethylene (TCE) and development of clinical parkinsonism. Animal models of TCE exposure have shown nigrostriatal degeneration and the development of parkinsonian features. Animal and cell culture models indicate mitochondrial dysfunction as the probable mechanism, most likely mediated by TaClo, a potential TCE metabolite. These observations endorse the hypothesis that a variety of environmental risk factors may cause nigrostriatal degeneration and clinical parkinsonism in genetically predisposed individuals. 
Trichloroethylene; Idiopathic Parkinson disease; Mitochondria; Alpha synuclein; Animal models 
OPPT REs
• OPPT_Trichloroethylene (TCE)_F. Human Health
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