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2142378 
Journal Article 
Dominant lethal testing of 7,12-dimethylbenz(a)anthracene with spermatogenic cells of mice 
Murota, T; Shibuya, T; Iwahara, S 
1981 
Yes 
Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X 
ELSEVIER SCIENCE BV 
AMSTERDAM 
HEEP/81/12984 
91 
273-277 
English 
HEEP COPYRIGHT: BIOL ABS. The polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) is a potent carcinogen which induces skin tumors and mammary tumors. Biochemical studies have shown that DMBA is a procarcinogen that requires metabolic activation by mixed-function oxidase systems. DMBA induces dominant lethal mutation testing in the germ cells of male mice.