Dominant lethal testing of 7,12-dimethylbenz(a)anthracene with spermatogenic cells of mice | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2142378

Reference Type

Journal Article

Title

Dominant lethal testing of 7,12-dimethylbenz(a)anthracene with spermatogenic cells of mice

Author(s)

Murota, T; Shibuya, T; Iwahara, S

Year

1981

Is Peer Reviewed?

Journal

Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X

Publisher

ELSEVIER SCIENCE BV

Location

AMSTERDAM

Report Number

HEEP/81/12984

Volume

Issue

Page Numbers

273-277

Language

English

PMID

6787421

DOI

10.1016/0165-7992(81)90045-2

Web of Science Id

WOS:A1981LN98100021

URL

https://linkinghub.elsevier.com/retrieve/pii/0165799281900452
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Abstract

HEEP COPYRIGHT: BIOL ABS. The polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) is a potent carcinogen which induces skin tumors and mammary tumors. Biochemical studies have shown that DMBA is a procarcinogen that requires metabolic activation by mixed-function oxidase systems. DMBA induces dominant lethal mutation testing in the germ cells of male mice.