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2142951 
Journal Article 
Dietary Modification of Intestinal and Pulmonary Aryl Hydrocarbon Hydroxylase Activity 
Wattenberg, LW 
1972 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
NIOSH/00208772 
23 
4 
741-748 
English 
4118879 
The activity of aryl-hydrocarbon-hydroxylase (AHH) in the intestines and lungs was reviewed through quantitative and histochemical studies of the localization of AHH. Emphasis was placed on dietary factors which affect the AHH level of activity in these tissues. Data relating the role of AHH in the protection of the body against chemical carcinogens were also presented. Early studies of this protective property showed that AHH markedly reduced the incidence of hepatic cancer caused by 3'-methyl-4-dimethylaminoazobenzene (55801) in rats. Other studies demonstrated marked reductions in the incidence of tumors in rats fed 2-acetylaminofluorine (53963) or 7-fluoro-2-acetylaminofluorene (343895). In the latter, reactivation resulted from ring hydroxylation of the carcinogen. Recent studies suggest that the activation of AHH activity protects against carcinogenic polycyclic hydrocarbons, as in the protection afforded against mammary tumor formation in animals given 7,12-dimethylbenz(a)anthracene (57976) (DMBA). The author states that studies will continue for some time to determine the actual mechanism through which this protective effect is demonstrated.