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2144133 
Journal Article 
Oestrogen receptor activity and endocrine status in DMBA-induced rat mammary tumours 
Hawkins, RA; Hill, A; Freedman, B; Killen, E; Buchan, P; Miller, WR; Forrest A, PM 
1977 
Yes 
European Journal of Cancer
ISSN: 0959-8049
EISSN: 1879-0852 
HEEP/77/10009 
13 
3 
223-228 
English 
HEEP COPYRIGHT: BIOL ABS. Estrogen receptor activity (unfilled sites) was determined in DMBA (7,12-dimethylbenz(a)anthracene) induced rat mammary tumors and at sacrifice, the plasma concentrations of estradiol-17beta and prolactin were determined by radioimmunoassay. In intact animals, receptor levels fluctuated in inverse relationship with the plasma estrogen concentration, but following ovariectomy, levels were significantly reduced. Administration of estrogen to ovariectomized animals did not detectably change receptor levels, but administration of perphenazine significantly increased receptor levels toward those seen in intact animals. In animals bearing 2 or more tumors, similar receptor concentrations were detected in tumors from the same animal. The concentration of estogen receptor sites in rat mammary tumors is influenced by circulating levels of estrogen prolactin.