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2145793 
Technical Report 
Toxicity Of 90Sr In Fused Aluminosilicate Particles Inhaled By Beagle Dogs. VI 
Snipes, MB; Boecker, BB; Hahn, FF; Hobbs, CH; Mauderly, JL; Mcclellan, RO; Pickrell, JA 
1975 
NIOSH/00155972 
Lovelace Foundation for Medical Education and Research 
LF-52 
173-177 
The toxicity of strontium-90 (10098972) fused aluminosilicate particles was studied in beagle-dogs. A total of 124 dogs, 106 experimental and 18 controls, was used. Size distributions of the particles ranged from 1.4 to 2.8 micrometers. Initial lung burdens (ILB) ranged from 0.21 to 94 microCuries strontium-90 per kilogram (microCi/kg). Of the 106 exposed dogs, 32 exposed to particles with ILB of 29 to 94microCi/kg and doses to the lung of 40,000 to 96,000 rads died of radiation pneumonitis and pulmonary fibrosis at 159 to 477 days after exposure. The major pathological findings were severe radiation pneumonitis, severe pulmonary fibrosis, acute and chronic vascular lesions, bullous emphysema, right ventricular dilation and hypertrophy, and severe atrophy and fibrosis of the tracheobronchial lymph nodes. Seventeen dogs exposed to particles with ILB ranging from 8.9 to 36microCi/kg and doses to the lung of 31,000 to 68,000 rads died of hemangiosarcomas at 644 to 1,807 days after exposure. Clinical signs were related to massive thoracic hemorrhage, a direct result of pulmonary tumors. Three of the dogs developed hemangiosarcomas that metastasized widely. Metastases were found in the lung, brain, adrenal gland, and kidney. Mild radiation pneumonitis, pulmonary fibrosis, and chronic passive congestion of the liver were also found in these three dogs. The authors conclude that neoplasms induced by strontium-90 are similar to those seen in dogs exposed to cerium-144 (14762788). Thoracic structures other than lungs are also considered at risk for tumor production after inhalation of beta emitting radionuclides.