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2147642 
Journal Article 
Abstract 
Subacute 2-AAF toxicity in C57BL/6 and BALB/c strain mice 
Schieferstein, G; Haley, TJ 
1974 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
29 
1 
105 
English 
is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974
Ninety-day subacute toxicity of 2-acetylaminofluorene (2-AAF) has been determined in 1200 mice each of the C57BL/6 and BALB/c strains equally divided between the sexes. The concentrations of 2-AAF were 0.05, 0.025, 0.01, 0.005 and 0.001% of the diet. No signs of toxicity were seen. Slight weight reduction was seen in the C57BL/6 males and BALB/c females at the 0.05% AFF level. A dose-dependent urinary bladder epithelial hyperplasia was seen in both strains and the males were more susceptible than the females. Squamous metaplasia of the uroepithelium was observed in the BALB/c mice with this effect greater in the males. One BALB/c male at the 0.025 and 0.05% levels had bladder carcinoma. Adrenal gland spindle cell hyperplasia was greater in the females of both strains. Bladder concretions were observed in males of both strains. No other significant histopathological changes were observed. The data obtained will be utilized in the design of the large chronic studies to be conducted at NCTR. 
Thirteenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 10–14, 1974