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2147645 
Journal Article 
Abstract 
Chronic dose-response studies in mice fed 2-acetylaminofluorene (2-AAF) 
Littlefield, NA; Cueto Jr., C; Davis, AK; Medlock, K 
1974 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
29 
1 
106 
English 
is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974
Large numbers of mice have been exposed to 2-acetylaminofluorene (2-AAF) in the diet in order to provide quantitative information on carcinogenic dose-response relationships. Weanling BALB/c and C57BL/6 mice of both sexes were fed 2-AAF ad libitum in their diet for 18 months at concentrations of 0, 100, 150 and 500 ppm. Occurrence of bladder tumors was considered as the endpoint for determination of dose-response curves. Data were accumulated from mice that died during the 18-month period, from moribund mice on which a necropsy was performed and from mice on which the necropsy was performed at the terminal sacrifice after 18 months of exposure to the carcinogen. The results from an interval sacrifice after 1 year of exposure to the high dose showed 38 and 88% incidence of bladder tumors in the BALB/c males and females, respectively, while the C57BL/6 mice exhibited a bladder tumor incidence of 29% in the males and 11% in the females. The results exhibited both a sex-related and a strain-related difference in response to 2-AAF. The BALB/c mice appeared to be more susceptible to early development of bladder tumors than the C57BL/6 mice. 
Thirteenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 10–14, 1974