US EPA

2221518 

Journal Article 

Ultraviolet hypochromism in the interaction systems of DNA and carcinogenic 2-anthramine and its related compounds 

Okano, T; Takenaka, S; Horie, T; Kano, T 

1974 

1 

Gann
ISSN: 0016-450X 

65 

1 

33-44 

English 

4856890 

Electronic interaction between DNA and 2 anthramine, which inducs skin tumors and related compounds, was studied. Combined systems of calf thymus DNA with 1, 2, and 9 anthramines and n, n dimethyl 2 anthramine produced hypochromism, and secondary structure of DNA was indispensable for production of hypochromism, and there was an optimum salt concentration for the spectroscopic change. The degree of hypochromic change expressed by the ingegrated intensity and the degree of spectral overlapping of perturbants were parallel. Amon the compounds examined, the carcinogenic 2 anthramine gave the hight value of percentage hypochromicity at 260 nm. The molecular action mechanism of 2 anthramine from the viewpoint of elecgronic perturbation of DNA by the carcinogen, and the molecular specificity of 2 anthramine are discussed.