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2222484 
Journal Article 
AN INHIBITORY EFFECT OF STEROIDS ON 20-METHYLCHOLANTHRENE- AND 7,12-DIMETHYLBENZ(A)-ANTHRACENE-INDUCED RAT MAMMARY TUMORS 
Harada, T; Rooks, WH; Dorfman, RI 
1965 
1 
Oncology: International Journal of Cancer Research and Treatment
ISSN: 0030-2414
EISSN: 1423-0232 
19 
1 
3-10 
English 
14285013 
The uptake of glycine-2-C14 into proteins of 20-methylcholanthrene and 7,12-dimethylbenz[a]anthracenc-induced rat mammary tumors may be inhibited by 2 methyl-17p,-hydroxy-5a-androstan-3-one. The corresponding 17a-methyl derivative also inhibited glycine uptake by the proteins of 20-methylcholanthrene-induced tumors. These carcinogen-induced mammary tumor systems may, under the conditions described here, serve as possible assay methods for evaluating the anti-mammary tumor activity of steroids. © 1965 S. Karger AG, Basel.