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2223386 
Journal Article 
THE BIOAVAILABILITY AND PHARMACOKINETICS OF MORPHINE AFTER INTRAVENOUS, ORAL AND BUCCAL ADMINISTRATION IN HEALTHY-VOLUNTEERS 
Hoskin, PJ; Hanks, GW; Aherne, GW; Chapman, D; Littleton, P; Filshie, J 
1989 
Yes 
British Journal of Clinical Pharmacology
ISSN: 0306-5251
EISSN: 1365-2125 
27 
4 
499-505 
English 
2719903 
WOS:A1989U124300014 
1. The absolute bioavailability of morphine from oral aqueous solution, a controlled release oral tablet (MST-Continus) and a controlled release buccal tablet has been investigated in six healthy volunteers. 2. Analysis of plasma samples for morphine and its active metabolite morphine-6-glucuronide (M6G) was by means of a differential radioimmunoassay technique. Absolute bioavailability for morphine was estimated to be 23.9% after oral solution, 22.4% after MST-Continus and 18.7% after the buccal tablet. Maximum plasma morphine concentrations were seen at 45 min (oral solution), 2.5 h (MST) and 6 h (buccal). 3. There was no difference in the amount of M6G appearing in plasma after intravenous, oral or buccal administration but the mean ratio of AUCs for M6G: morphine in plasma after intravenous morphine was 2 : 1 compared with 11 : 1 after oral and buccal morphine.