Health & Environmental Research Online (HERO)


Print Feedback Export to File
2239748 
Journal Article 
Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration 
Han, C; Jung, P; Sanders, SW; Lin, ET; Benet, LZ 
1994 
Yes 
Biopharmaceutics and Drug Disposition
ISSN: 0142-2782
EISSN: 1099-081X 
IPA/95/1080529 
15 
2 
179-183 
English 
8011969 
IPA COPYRIGHT: ASHP A randomized crossover study of the pharmacokinetics of nitroglycerin and its 4 metabolites was conducted in 6 healthy adult males who received a 2 nitroglycerin transdermal patch formulations designed to deliver 16.8 mg/day drug or 15 mg/day drug (Transderm-Nitro). Mean steady state levels were 16-16.5 nmol/l for 1,2-dinitroglycerin, 3.32-3.82 nmol/l for 1,3-dinitroglycerin, 0.79-1.13 nmol/l for nitroglycerin, 33.5-33.7 nmol/l for 1-mononitroglycerin (glyceryl 1-nitrate), and 188.2-203 nmol/l for 2-mononitroglycerin (glyceryl 2-nitrate). Steady state levels for the formulations showed no significant differences in terms of parent drug and metabolites, either when measured values were compared or when Transderm-Nitro values were multiplied by 1.12 to account for the difference in dosages. In all subjects, 1,2-dinitroglycerin was the predominant dinitrate and 2-mononitroglycerin was the predominant mononitrate.