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2240799 
Journal Article 
Site dependence for topical absorption of nitroglycerin in rats 
Horhota, ST; Fung, HL 
1978 
Yes 
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 
IPA/79/360204 
67 
9 
1345-1346 
English 
99511 
IPA COPYRIGHT: ASHP The effect of the site of application on nitroglycerin (Nitro-Bid; I) absorption from ointments was studied in rats. I was applied to the rats either on an abdominal site or a back site near the tail. Blood samples were drawn in 0.5 ml increments from a cannula implanted in the right jugular vein. Plasma I levels could not be detected after application of a 2% I ointment (7 and 14 mg/kg) or a 6.9% alcohol solution (8, 15 and 20 mg/kg) to the back site. The abdominal site showed rapid drug absorption following the 2% ointment with peak plasma levels ranging between 30 and 40 ng/ml. The implications of these results regarding systemic effects of I ointment and the choice of proper animal models for screening topically delivered drugs are discussed.