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2241788 
Journal Article 
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma 
Das, R; Bhattacharya, K; Sarkar, S; Samanta, SK; Pal, BC; Mandal, C 
2014 
Yes 
Apoptosis
ISSN: 1360-8185
EISSN: 1573-675X 
19 
1 
149-164 
English 
24052409 
WOS:000329294000011 
has retraction 11922692 (vol 19, pg 149, 2014) (Retraction of Vol 19, Pg 149, 2014)
5-Fluorouracil (5-FU) alone or in combination with other drugs is the main basis of chemotherapeutic treatment in colorectal cancer although patients with microsatellite instability generally show resistance to 5-FU treatment. The present investigation is focussed on the mechanistic insight of a pure herbal carbazole alkaloid, mahanine, as a single or in combination with 5-FU in colon cancer. We demonstrated that mahanine-induced apoptosis involved reactive oxygen species (ROS)-mediated nuclear accumulation of PTEN and its interaction with p53/p73. Mahanine and 5-FU in combination exerted synergistic inhibitory effect on cell viability. This combination also enhanced ROS production, increased tumour suppressor proteins and suppressed chemo-migration. Taken together, our results revealed that mahanine can be a potential chemotherapeutic agent with efficacy to reduce the concentration of toxic 5-FU in colon cancer. 
5-Fluorouracil; Mahanine; Colon cancer; PTEN; p53; p73