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2242420 
Technical Report 
Carcinogenic nitrogen compounds: LXXIV. Skraup and Combes-Beyer reactions with 3-aminocarbazoles: A new route to pyrideo-(3,2'-b) carbazoles 
Perche, JC; Saint-Ruf, G; Buu-Hoi, NP 
1972 
HEEP/73/01146 
2 
260-262 
HEEP COPYRIGHT: BIOL ABS. 3-Amino-9-ethyl- and 3-amino-9-ethyl-6-methyl-carbazole follow Marckwald's rule in the Skraup reaction, to give derivatives of 7H-pyrido(2,3-c)carbazole. The same amines undergo anti Marckwald cyclizations in the Combes-Beyer reaction, to give derivatives of the linear 6H-pyrido(3,2-b)carbazole, which are analogues of the carcinostatic alkaloid ellipticine.