US EPA

2248397 

Journal Article 

A new alcohol provocation head tip tilt protocol in the patients with alcohol-related syncope 

Tateoka, K; Iwasaki, Yuki; Ono, T; Kobayashi, Y; Katoh, T; Takano, T 

2007 

Yes 

Europace
ISSN: 1099-5129
EISSN: 1532-2092 

9 

4 

220-224 

English 

17347329 

10.1093/europace/eum025 

WOS:000246291600005 

AIMS: Drinking alcohol is known to be one of the triggering factors of neurally-mediated syncope. Little is known about the diagnostic utility of the conventional and alcohol provocation head up tilt-test (HUT) in patients with alcohol-related syncope. We investigated the effect of the alcohol provocation HUT.

METHODS AND RESULTS: We studied 12 patients (8 males, age 51 +/- 19 years) who had a history of unexplained post-alcohol ingestion syncope. An alcohol provocation protocol HUT (alcohol HUT), in which the protocol required 350 mL of 5% alcohol beer to be drunk over 5 min followed by positioning with the table tilted up for up to 30 min, was performed after the control and isoproterenol (ISP) HUT. None of the subjects (0/12) exhibited a positive response in the control HUT, and only one subject had a positive response (1/12; 8.3%) in the ISP HUT. In the alcohol HUT a positive response (9/12; 75%) increased in the patient group, whereas there were no positive responses in the normal control group.

CONCLUSION: In the conventional HUT protocols, including ISP provocation, it was difficult to produce a positive response in the patients with alcohol-related syncope. Alcohol ingestion was a useful diagnostic provocation method in such patients. 

alcohol; head up tilt-test; provocation test; neurally-mediated syncope