Cyclic AMP as a mediator of the relaxing action of papaverine, nitroglycerine, diazoxide and hydralazine in intestinal and vascular smooth muscle | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2250327

Reference Type

Technical Report

Title

Cyclic AMP as a mediator of the relaxing action of papaverine, nitroglycerine, diazoxide and hydralazine in intestinal and vascular smooth muscle

Author(s)

Andersson, R

Year

1973

Is Peer Reviewed?

Yes

Journal

Acta Pharmacologica et Toxicologica
ISSN: 0001-6683

Report Number

IPA/74/121082

Volume

Toxicol

Issue

REF 33

Page Numbers

321-336

Language

eng

Abstract

IPA COPYRIGHT: ASHP The role of cyclic AMP in mediating in drug-induced smooth muscle relaxation and vasodilation is discussed. Relaxation of rabbit colon muscle, by papaverine and nitroglycerin, and bovine mesenteric artery, by diazoxide and hydralazine, correlated well with an increased muscle content of cyclic AMP and decreased ATP content of the respective sections. These actions were found to be calcium dependent and involved inhibition of phosphodiesterase activity in calcium-binding microsomal fractions like mitochondria.