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2250830 
Journal Article 
Visual compatibility of ranitidine hydrochloride with commonly used critical care medications 
Chilvers, MR; Lysne, JM 
1989 
Yes 
American Journal of Hospital Pharmacy
ISSN: 0002-9289 
IPA/90/876678 
J 
REF 3 
2057-2058 
eng 
IPA COPYRIGHT: ASHP The visual compatibility of ranitidine hydrochloride (I) injection with commonly used critical-care medications was studied under conditions simulating Y-site administration; one ml of I was mixed in glass vials with one ml of each secondary additive being tested. Drugs tested for compatibility with I included cardiac drugs (bretylium tosylate, procainamide hydrochloride), sympathomimetic agents (dobutamine hydrochloride, dopamine hydrochloride), aminophylline, heparin sodium and nitroglycerin. Samples drawn up in disposable plastic syringes were examined at 30 min and 1, 2, 4, 8, and 24 h after preparation for turbidity, haze, precipitation, gas production, color changes, and other signs of visual incompatibility. No visible signs of incompatibility were noted during the 24 h study period in any of drug combinations investigated. At concentrations tested, I appeared to be visually compatible with other injectable drugs commonly administered to critically ill patients.