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2250851 
Journal Article 
Beneficial effects of trimetazidine in men with stable angina under beta-blocker treatment 
Michaelides, AP; Vyssoulis, GP; Bonoris, PE; Psaros, TK; Toutouzas, PK; Et al 
1989 
Yes 
Current Therapeutic Research
ISSN: 0011-393X 
IPA/90/899207 
Ther 
REF 15 
1989 
eng 
IPA COPYRIGHT: ASHP An open study of the effects of trimetazidine (I) when added to beta blocker therapy was conducted in 18 male patients with stable angina who received placebo plus beta blocker therapy for one month and subsequently received the same dose of beta blocker for an additional 3 months in combination with I, administered in oral tablet form; sublingual nitroglycerin (II) consumption was unlimited. Patients underwent a treadmill stress test (TST) before and after the placebo period and after one and 3 months of therapy with I and a beta blocker. One patient dropped out of the study after the second month of I therapy due to insufficient improvement. During I treatment, there was a significant improvement in exercise capacity and a reduction in exercise induced ischemia as shown by electrocardiogram changes. No difference was observed in systolic blood pressure at maximum workload between the 2 treatment periods, although heart rate increased slightly during I therapy. Throughout the I period, anginal attacks were fewer and II consumption fell. No side effects were attributed to I. It was concluded that I improves the anginal syndrome and work capacity of patients with stable angina receiving beta blocker therapy.